Each of these chapters starts with a concise but up-to-date 

 account of normal development, which is concluded by a brief 

 summary of critical events. Wherever needed recent histochemical, 

 ultrastructural, or experimental-embryological data are included. 

 In the main part of each chapter each separate anomaly is usually 

 treated successively from the viewpoints of anatomy, embryogene- 

 sis, history, incidence, symptoms, diagnosis, and treatment. 

 Each chapter has a summary table of the anomalies described 

 (stating time of origin and first appearance, sex chiefly af- 

 fected, and relative frequency) and an extensive bibliography. 



The book is beautifully printed and illustrated. The great ma- 

 jority of figures are taken from other authors, but there are 

 several good original figures and diagrams. The subject index 

 covers 21 pages. 



47. 



J.WARKANY. 1971. CONGENITAL MALFORMATIONS. Notes and Comments 

 Year Book Med. Publ., Chicago. XL, 1309 pp., 660 figs., 12 tabs., 

 subject index. $ 60.00, £ 31.50 



The author of this impressive volume is a renowned pedia- 

 trician and at the same time one of the founders of mammalian 

 experimental teratology. The subtitle of the book is definitely 

 over-modest; it is difficult to imagine how a work written by a 

 single author could be more comprehensive. We must be thankful 

 to the author for making his vast experience available to oth- 

 ers . 



The bulk of the book (Parts IV-XIX) consists of 121 chapters 

 of varying length dealing with structural malformations in man 

 selected because of common occurence or emphasis in the litera- 

 ture; they are arranged in 13 parts mainly according to organs 

 and organ systems. The longer chapters discuss what is known 

 about the genesis and etiology of the malformation, as well as 

 the relevant results of animal experiments. Part I of the book 

 (50 pp.) presents general considerations; of the seven chapters 

 we mention Definitions, Present trends in teratology, Beginnings 

 of experimental mammalian teratology, Syndromes, and Sensitive 

 or critical periods in teratogenesis : uses and abuses of embryol- 

 ogic timetables. All of these contain valuable critical and cau- 

 tionary notes. Part II (5 chs., 75 pp.) deals with etiological 

 factors generally, and is restricted to well-established facts. 

 Part III (9 chs., 5^ pp.) deals with general disturbances of 

 growth and development; the longest chapter is that on intra- 

 uterine growth retardation. Separate chapters on the following 

 subjects were considered but deliberately omitted: inborn errors 

 of metabolism (now a separate discipline), dental malformations, 

 twins and conjoined twins, and monstrosities. 



The book is very well produced and profusely illustrated with 

 photographs and photo-micrographs, most of them original. Al- 

 though the author states that the literature cited is far from 

 exhaustive, the amount is nevertheless impressive; many non- 

 English titles are included. The index is detailed and well 

 laid-out . 



205 



