Monographs 



48. 



E.FREDERIKS. 1973. VASCULAR PATTERN IN EMBRYOS WITH CLEFTS OF 



PRIMARY AND SECONDARY PALATE 



Springer, Berlin, etc. Ergebn. Anat . Entw.gesch. Bd.46, H.6. 



50 pp., 35 figs., 2 tabs. ca. £ 6.49 (paper) 



Extension of a study published in Brit. J. Surg. 2_5, 1972; sum- 

 mary of vascular patterns in normal human embryos of 8-50 mm. ; 

 detailed description of patterns in six cleft embryos of 13-64 

 mm.; good graphical reconstructions; hypothesis that vascular 

 depletion is the cause of cleft formation is rejected. 



49. 



A.L.ROMANOFF with the collaboration of A.J.Romanoff. 1972. 

 PATHOGENESIS OF THE AVIAN EMBRYO, an analysis of causes of mal- 

 formations and prenatal death 



Wiley-Interscience, New York, etc. XVI, 476 pp., 192 figs., 21 

 tabs., subject index. £ 9.45 



Contents: I. Dynamics of development; II. Spontaneous malfor- 

 mations; III. Genetic mutations; IV. Atmospheric changes; V. 

 Ionizing radiation; VI. Nutritional deficiency; VII. Chemical 

 teratogenicity; VIII. Hormonal derangement; IX. Pathogenic af- 

 flictions; X. Traumatic disturbance; XI. Aberrant twinning 



This monograph is comparable in scope to the author's earlier 

 book "Biochemistry of the Avian Embryo" (1967). It is essential- 

 ly compilatory in nature, and is based on the close scrutiny of 

 more than 6,000 published papers, of which about 900 appear in 

 the bibliography. The significant experimental data were care- 

 fully evaluated, frequently recalculated, and a large proportion 

 were condensed into tables and composite original graphs. The 

 material is presented without discussion or interpretation. The 

 result is an invaluable source book, which however is no substi- 

 tute for a text on avian teratogenesis . 



The chapters are subdivided into numerous subsections, and al- 

 most any conceivable teratogenic agent or environmental factor 

 is considered. The tables are of considerable help in obtaining 

 a quick overview of published work in certain areas, and this 

 is particularly true of the nine extensive summary tables ap- 

 pended to ch.III and chs.V-IX. Most of the material of course 

 relates to the chick, but other avian species are considered 

 wherever material is available. A 12-page appendix deals with 

 miscellaneous items, particularly the natural variability in 

 various characteristics of chicken eggs which can be of signif- 

 icance in experimental work. Finally, there is a glossary of 

 Greek names of congenital malformations. 



The book is well produced but very expensive. The original 

 line drawings are successful. Most of the titles in the bibliog- 

 raphy are older than 1969. The bibliography also serves as an 

 author index. The subject index is comprehensive and cross-ref- 

 erenced . 



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