22 



The book has an introduction by Prof. H. B. Fell, and is in two parts, 

 Animal and Plant tissue culture respectively. Part I is subdivided into three 

 sections, 1) Organ and explant culture (9 papers), 2) Cell culture (12 

 papers), and 3) Tissue culture in virology (7 papers). Section 1 has two 

 introductory papers by H. B. Fell ("The technique of organ culture" and 

 "The application of organ culture to medical and biological research"). It 

 furthermore contains three papers on chick embryo long bones in vitro (two 

 by Japanese and one by Indian workers). Section 2 has an introductory paper 

 by J. Paul ("Animal cell culture in cell biology research"). Nine out of the 

 12 papers in this section are by British and American workers. 



One of the 16 papers of Part II may be mentioned specifically: "Morpho- 

 genesis in tissue cultures; totipotency of cultured cells" by Mohan Ram and 

 Mridul Wadhi. Most of the other papers will be of interest to students of 

 plant embryology and morphogenesis. 



The book is adequately illustrated and concluded by author and subject 

 indexes. 



20. EMBRYOPATHIC ACTIVITY OF DRUGS 



1965 



Editors: J. M. Robson, F. M. Sullivan J. & A. Churchill Ltd. 



& R. L. Smith London 



317 pp., 32 figs., 40 tbs. Price: 60s. 



Invited participants.- Beck (Cardiff), Bergel (London), Binns (Logan, Utah), Cahal (London), 

 Cohen of Birkenhead (Liverpool), Fabro (London), Faigle (Basel), Fouts (Iowa City, Iowa), 

 Fritz (Basel), Gillman (Cambridge), Giroud (Paris), Hamilton (London), Hunter (Sitting- 

 bourne), Jackson (Manchester), Keberle (Basel), Kelsey (Washington, D.C.), Kniisel (Basel), 

 Lenz (Hamburg), Lloyd (Cardiff), Loustalot (Basel), Lutwak-Mann (Cambridge), Mann (Cam- 

 bridge), Poulson (London), Robson (London), Schmid (Basel), Schumacher (London), Slater 

 (Harrow), Smith (London), Smithells (Liverpool), Somers (Hull), Sullivan (London), Tuch- 

 mann-Duplessis (Paris), Venning (Bucks), Williams (London). 



The Symposium of which this book contains the proceedings was held in 

 March 1965 in London under the auspices of the Biological Council. There 

 were 34 invited participants, 12 of whom came from various countries outside 

 Great Britain. The audience consisted of more than 400 medical and biological 

 scientists. 



The book contains 16 papers, most of which are concerned with drug- 

 induced malformations in mammals and man. Three papers deal with the 

 chemistry, metabolism, and mechanism of action of thalidomide; two papers 

 discuss the evaluation of data on congenital malformations in human pop- 

 ulations, while two other papers deal with legal aspects of the problem. The 

 book opens with two contributions of a general nature, one on embryological 

 principles of teratogenesis (Beck and Lloyd, 20 pages), and one on pharmac- 

 ological principles of teratogenesis (Robson, Poulson, and Sullivan, 14 pages). 



The Symposium was organized in sessions of two papers each, and each 

 session was concluded by a discussion in which also members of the audience 

 participated. The discussions are recorded; they occupy about a quarter of 

 the book, and contain much additional information, including literature ref- 

 erences. 



The book is well-printed and adequately illustrated. It is concluded by a 

 subject index. 



