Monographs 



33. 



R.B.ROSS and M.C.JOHNSTON. 1972. CLEFT LIP AND PALATE 



Williams & Wilkins, Baltimore. X.3 1 9 pp., 232 figs., 9 tabs., subject index. $ 24.50 



This book was written primarily for students and clinicians, but will also be useful to 

 teratologists. This holds particularly for the non-clinical chapters. One of the purposes of 

 the book was to compile and interpret the often contradictory and confusing literature, 

 and to integrate the data from animal experiments and human population studies. The 

 discussions are placed against a broad embryological background. The clinical chapters 

 will not be considered here. 



A basic chapter is of course that on Normal embryonic development of the face 

 ( 14 pp.). The next two chapters are: Cleft lip with or without cleft palate (30 pp.) and 

 Isolated cleft palate (21 pp.), each with long sections on embryogenesis and etiology. 

 Then follows a chapter on Facial development from cleft formation to birth — Defi- 

 ciences and distortions (14 pp.) The other non-clinical chapters we mention are Growth 

 of the normal face (from infancy to adulthood; 15 pp.) and Facial growth in unrepaired 

 cleft lip and palate (7 pp.). A brief final chapter contains reflections on etiology and 

 prevention. A number of appendices present numerical data on the incidence of facial 

 clefts in relation to race, sex, and age, on malformations associated with facial clefts, on 

 familial relationships (including computation of heritability values), and on concordance 

 in twins. 



The book is very well produced and admirably illustrated with line drawings and 

 photographs. 



Reference works 



34. 



T.H.SHEPARD. 1973. CATALOG OF TERATOGENIC AGENTS 



Johns Hopkins Univ. Press, Baltimore, etc. XXII,211 pp., author and subject indexes. 

 $ 10.- 



This catalog lists over 500 agents with teratogenic or suspected teratogenic activity: 

 chemicals, drugs, physical factors, and viruses. It is based on a careful scrutiny of the 

 literature reporting experiments on birds and mammals. Each entry contains a brief 

 account of published work selected for its review nature, originality, or currency. The 

 account considers species, dose, gestational age at time of administration, and type of 

 defects produced (sometimes absence of effects). The most recent literature cited dates 

 from 1972; the author envisages future revisions and solicits the cooperation of the 

 readers to fill up gaps. 



The book has been composed by computer, which has reduced the time of production 

 and facilitates future revisions. The endpapers carry a very useful comparative time table 

 of development in man, rhesus monkey, rat, mouse, rabbit, golden hamster, Guinea pig, 

 and chick. 



182 



