to give an overview of the sequence of development and decline of the organism from 

 conception to death; to focus upon the functional changes that mark critical stages of 

 development and aging, with emphasis upon the interrelationships among various func- 

 tions and processes and with time; and to integrate classic theories with current hypo- 

 theses and experimental research. Thus, discrete events at the molecular, cellular, and 

 tissular levels have been chosen essentially on the basis of their contribution to overall 

 physiologic competence at selected ages. Similarly, the development and the aging of 

 endocrine and nervous systems have been given particular emphasis, because of their 

 significant role in regulating all bodily functions and in enabling the organism to 

 respond to internal and external environmental challenges from birth to old age. 



The author has solicited the help of six other contributors for seven of the 31 

 chapters. Optional reading, mostly of an advanced nature, is set in smaller type. The book 

 is very well produced and illustrated, and all chapters have extensive and up-to-date 

 bibliographies. The index is very extensive. 



Symposium reports 



81. 



H.ANKERMANN and A.TRAEGER, eds. 1972. BEITRAGE ZUR ENTWICKLUNGS- 



PHARMAKOLOGIE 



Friedrich Schiller Univ., Jena. Wissenschaftliche Beitrage der Friedr.-Schiller Univ 

 230 pp., 102 figs., 13 tabs. ca. M 14.- (paper) 



This book contains the 28 papers read at an international and interdisciplinary 

 symposium held in November 1971 in Jena, East Germany. Half of the papers were by 

 East and West-German groups, while the remaining contributions came from Czechoslo- 

 vakia, the U.S.S.R., Sweden, and the U.S.A. The majority of the papers are in German; 

 four are in English. 



The subject is considered from the viewpoints of pharmacology, pre- and postnatal 

 developmental biology, pediatrics, and gynecology. At least a dozen of the papers are of 

 potential interest to mammalian developmental physiologists and teratologists. 



The book is plainly produced and has only line illustrations. 



82. 



B.K.FORSCHER and J.C.HOUCK, eds. 1973. CHALONES: concepts and current re- 

 searches 



U.S. Dept. of Health, Education, and Welfare, Bethesda. National Cancer Inst. Monograph 

 38. VIII, 233 pp., 88 figs., 39 tabs. $ 4.75 



Chalones are tissue-specific endogenous mitotic inhibitors. This symposium was held in 

 Augusta, Mich, in June, 1972. According to the preface "almost every significant 

 investigator of chalones over the past decade" was invited. The participants came from 

 North America and a number of Western-European countries. 



The 23 papers are arranged in three groups as follows: The epidermal chalone (7 

 research papers, a review by Laurence, and a summary of mechanisms by Bullough); The 

 leucocyte chalone (a review by Lajtha and 6 research papers); Miscellaneous chalones (7 

 papers on fibroblast, liver, kidney, melanocyte, and tumor chalones). Furthermore, there 

 is an introductory review by Bullough, a paper by Bard on chalones and homeostasis, and 

 an apt summary of the symposium by Iversen. The discussions held at the symposium are 

 not recorded. There are no indexes. 



201 



