other physical agents, 6. Infectious diseases, 7. Nutritional deficiencies 

 and excesses, 8. En±iryotoxicity of drugs in man, 9. Environmental chemi- 

 cals, 10. Maternal metabolic and endocrine imbalances, 11. Atmospheric 

 gases - variations in concentration and some common pollutants, 12. Ex- 

 tremes of temperature, 13. Interactions and multiple causes. 



Contents vol.2: ill. initiating mechanisms and early pathogenesis: 1. Gene 

 expression and its regulation, 2. Developmental genetics, 3. Numerical and 

 structural chromosome abnormalities, 4. Cell death and reduced prolifera- 

 tive rate, 5. Altered biosynthesis, 5. Embryonic intermediary metabolism 

 under normal and pathological conditions, 7. Altered electrolyte and fluid 

 balance, 8. Abnormal cellular and tissue interactions, 9. Cell morphogene- 

 tic movements, 10. Alterations in the metabolism of glycosaminoglycans and 

 collagen, 11. Time-position relationships, with particular reference to 

 cleft lip and cleft palate, 12. Teratogenesis and oncogenesis; IV. Exam- 

 ples of abnormal organogenesis: 13. Abnormal organogenesis in the eye, 14. 

 Abnormal organogenesis in the cardiovascular system, 15. Abnormal organo- 

 genesis in the urinary tract, 16. Abnormal organogenesis in the reproduc- 

 tive system, 17. Abnormal organogenesis of facial structures, 18. Abnormal 

 organogenesis in the limbs. 



Contents vol.3: v. Maternal and placental effects: 1. Maternal and cyto- 

 plasmic effects in experimental teratology, 2. Factors that affect drug 

 concentrations in maternal plasma, 3. Effects of placental pathology on 

 the embryo and fetus; VI. Comparative studies in maxi and other mammals: 

 4. Summary of comparative embryology and teratology, 5. Comparative pla- 

 cental transfer; VII. Epidemiology: 6. Detection and evaluation of preg- 

 nancy wastage, 7. Value and methods of animal studies- in epidemiology, 8. 

 Birth defects registries and surveillance, 9. Correlations of malformation 

 frequency with environmental and genetic attributes in man 



Contents vol.4: VIII. Research procedures and data analysis: 1. Tech- 

 niques for cytogenetic analysis, 2. Mutation testing systems, 3. Cell, 

 tissue, and organ culture as teratologic tools, 4. Whole embryo explants 

 and transplants, 5. Survey of in vitvc systems: their potential use in 

 teratogenicity screening, 6. The structure and uses of genetically homo- 

 geneous lines of animals, 7. Multigeneration reproduction studies, 8- The 

 design of subprimate animal studies, 9. Feasibility and design of subhuman 

 primate studies, 10. Uterine vascular interruption and combined radiation 

 and surgical procedures, 11. Analytical techniques for the study of tera- 

 togenic mechanisms, 12. Immunological aspects of development, 13 Behav- 

 ioral teratology, 14. Methods and concepts of biometrics applied to tera- 

 tology 



One or more volumes of this monumental multi-author treatise have already 

 been reviewed and, on the whole, acclaimed in the scientific press (see e.g. 

 Nature 27d) . We list the tables of contents as a service to our readers. 



The work is a veritable mine of information and will be invaluable to all 

 teratologists and particularly to beginning investigators. Reviews such as 

 the chapters 2, 4, and 7-10 in vol.2 are also of interest to mammalian em- 

 bryologists generally (the authors are Gluecksohn-Waelsch, W.J.Scott, Jr., 

 Grabowski, Saxen, K.M.Yamada, and Kochhar and Larsson) . The same holds for 

 chs.4 and 5 in vol.3 (by Nishimura and Shiota, and Beck and Lloyd). 



The volumes are well produced and illustrated. 



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