Appendix I. 137 



upon him. Concerning the patellar-reflex data, the authors state (p. 54 of 

 their report, table 3, note 4), "his results are in the same direction (lengthened 

 latency and decreased amplitude of the reflex) as the average of the group, but 

 greater in degree." The effect of alcohol on the faradic threshold was in the 

 same direction and practically equal to the average for the group. 



Subject IX. — October 11, 1913, the statement is made in the history by 

 Dodge and Benedict as follows: Subject "drinks one-half to 1 bottle of wine or 

 beer a day now, but previously 3 bottles a day, in the evening; no general 

 effects. Largest amount taken, 4 bottles beer in the evening; did not feel 

 intoxicated, but vomited. Last use, previous evening 1 bottle of beer; no 

 effects. Never intoxicated. 2 or 3 liters of beer could be taken in the evening 

 without noticeable effects. Sometimes produced vomiting next day. In 

 excess of 2 or 3 liters it acted as a diuretic." October 20, 1913 (alcohol, dose 

 A), no statements given. October 27, 1913 (normal), 3 bottles of beer 1 day 

 before. November 3, 1913, Monday (alcohol, dose A), "during last week used 

 4 bottles of beer; Friday last, 3 bottles"; not discoverable whether the 3 was 

 in addition to the 4, thus meaning a total of 7. November 10, 1913, Monday 

 (normal), 2 bottles of beer previous Friday. November 17, 1913, Monday 

 (alcohol, dose A) , 2 bottles of beer on the 15th, 1 bottle of beer on the 16th. No- 

 vember 24, 1913, Monday (normal), "4 bottles of beer last Saturday night." 

 According to the personal history in Dodge and Benedict's report, this amount 

 was as much as the largest amount ever taken previous to the beginning of the 

 observation. December 1, 1913, Monday (alcohol, dose A), 2 bottles of beer 

 on the preceding Friday, and 2 on the preceding Wednesday. December 15, 

 1913 (alcohol, dose A), 1 bottle of beer taken 3 days before. December 22, 

 1913, Monday (normal, 12-hour experiment), "4 bottles of beer taken Satur- 

 day." December 23, 1913 (alcohol, dose C, 12-hour experiment), no state- 

 ments made. January 21, 1914 (alcohol, dose B), 6 bottles of beer during the 

 preceding week. January 29, 1914, Thursday (alcohol, dose B), 2 bottles of 

 beer on Sunday and 1 on previous Friday. February 20, 1914 (alcohol, dose 

 B), 1 glass of beer two days before. March 3, 1914, Tuesday (normal), 1 glass 

 of beer preceding Saturday. Subject IX, according to Dodge and Benedict's 

 table 50 (page 263 of their report) ranked second in prominent alcohol effect, 

 i. e., +2.0. 



Subject X. — February 11, 1913, largest amount and last time taken was on 

 December 15, 1912, 2 glasses of champagne at dinner. No statements are 

 made concerning the use of alcohol in the succeeding experiments, except for 

 that on March 11, 1913, at which time it was stated that no alcohol had been 

 used preceding the experiment. It is assumed that the same condition existed 

 for the other days. This subject was fourth in the order of alcohol effect. It 

 should be stated in this connection that he alone, of all the subjects, ate a full 

 meal at the laboratory immediately before the experiment (see Appendix II, 

 p. 139) and that only dose A was used on the 3 alcohol days of the 6 days on 

 which he served as subject. 



In estimating the susceptibility of an individual to the effects of a dose of 

 alcohol, account must be taken of the individual's habits. It is uncertain to 

 what extent the regular use of alcohol develops a tolerance for it and so reduces 

 the effects incident to the ingestion of a dose, or whether prolonged effects 

 have such an influence on the normal or control experiments as to reduce the 

 contrast between these and the alcohol experiments. The Dodge and Bene- 

 dict series indicates that those subjects who are practically abstainers show 

 more than an average alcohol effect. It may be said that in a short series of 

 experiments this will be due to psychical factors. These experiments were, 

 however, carefully designed to avoid this difficulty. Subject IV, and more 



