The 13 chapters are arranged in four groups as follows: New attitudes to experimental 

 teratology (4 chapters, with emphasis on genetic and cytotoxic factors); Problems of 

 predictive teratology (4); Influencing the fetal milieu (2, placenta and fetal surgery); New 

 aspects of developmental teratology (3, with emphasis on the CNS). 



The book is well produced and illustrated. 



63. 



D. A. GOOR and C. W. LILLEHEI. 1975. CONGENITAL MALFORMATIONS OF THE 



HEART, embryology, anatomy, and operative considerations 



Grune & Stratton, New York, etc. XVIII, 430 pp., 209 figs., 18 tabs., subject index. 



$32.50, £17.90 



This book, written by two distinguished cardiac surgeons, is of course primarily meant 

 for clinicians. However, since it is based on 20 years of combined embryological, clinical 

 and autopsy studies it contains many original anatomical and embryological findings 

 which can be of interest to embryologists and teratologists. Some of these findings have 

 not been published previously. 



We restrict ourselves to mentioning the first two chapters of the book, which together 

 occupy one quarter of the space. Ch.l deals with the anatomy (37 pp.) and ch.2 with the 

 embryology of the heart (65 pp.). Ch.2 consists of two parts entitled The heart and its 

 systemic tributaries, and The development of the pulmonary circulation (part II was 

 contributed by F. D. Skidmore). The remaining seven chapters deal with separate malfor- 

 mations and their surgical correction. 



The book is beautifully produced and superbly illustrated with many original line 

 drawings, micrographs, and photographs of dissection specimens. 



64. 



H. TUCHMANN-DUPLESSIS. 1975. DRUG EFFECTS ON THE FETUS, a survey of the 



mechanisms and effects of drugs on embryogenesis and fetogenesis 



ADIS Press, Sydney; Publ. Sciences Group, Acton, Mass. Monographs on Drugs Vol. 2. X, 



267 pp., 92 figs., 19 tabs., subject and author indexes. $ 31.00 



The author of this monograph is a leading French authority on experimental terato- 

 genesis. The book is probably of greatest use to pediatricians. It draws heavily on the 

 work of the author and his associates over long years, but is at the same time an 

 up-to-date, though highly selective review of the international literature. 



The basic embryological and genetic principles are clearly set out and attention is 

 devoted to the mechanisms of action of many drugs, in so far as they are known. 

 Screening methods are discussed. Apart from drugs, hormonal and nutritional imbalance, 

 metabolic disorders and radiation are also considered. 



The book is illustrated with many photographs and Ught micrographs and a number of 

 helpful diagrams; in the latter the captions are sometimes unclear or even deficient. 



Dissertations 



65. 



R. MEINIEL. 1975. CONTRIBUTION A L'ETUDE EXPERIMENTALE DE L'ACTION 



DES INSECTICIDES ORGANOPHOSPHORES SUR L'EMBRYON D'OISEAU 



Ph.D. thesis, Clermont. 213 pp., 1 1 figs., 30 pis., 15 tabs, (mimeographed) 



Teratogenic effects of parathion on chick and quail embryos; morphological, cytologi- 

 cal and (enzyme) histochemical studies; complementary studies with other drugs (reser- 

 pine, eserine) and protective agents; cytophysiological effects of acute parathion poiso- 

 ning (liver, muscle, adrenals); conclusion: primary effect on cholinesterases; excellent 

 photographs and light and electron micrographs. 



198 



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