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DISCUSSION 



Medawar: This is a most interesting paper. The problem is obviously 

 a very complex one, because there seem to be two levels of the ageing 

 process: there is the ageing in the individual gland, which is at least 

 partly a function of the cell population in the gland, and there is also 

 the ageing of the population of glands considered as a whole when the 

 number of functional units is decreasing. 



I would like to ask Prof. Montagna if it is possible that these two 

 processes are independent; and I also want to ask him if he has any 

 evidence that these glands atrophy or deteriorate and are then replaced. 

 I do not mean replaced de novo but replaced inside the old collagen 

 framework. I do not know whether his serial biopsy technique would 

 reveal such a process if it occurred; but if there were a progressive 

 deterioration in the replacement power of these glands, that might at 

 least account for the fall off in the number of functional units in the 

 population. 



Montagna: It is evident from our material that some glands become 

 aged more rapidly than others. I do not know whether or not the same 

 gland can recover. Mitotic activity can occur in the secretory cells of 

 aged tubules ; it is not abundant, but it is not abundant even in young 

 glands. It is possible that there might be some replacement of lost 

 segments. One point that should be made clear is that some glands do 

 fold up completely; not very many of them and not as often as one 

 would suspect, but some do perish. 



Harrison: You say you find no change or no evident change during 

 the menstrual cycle. How about during pregnancy, have you any 

 evidence of that? 



