THE GONADOTROPIC HORMONES 



stimulating hormone of "castrate" urine to be 5-10 times 

 greater than that of the ovaries. They obtained data on the 

 relationship between dose and uterine hypertrophy (see Figs. 

 14 and 15). In a later report Heller, Lauson, and Sevring- 

 haus (1938) particularly studied the response of the immature 

 rat's uterus. According to Bachman (1936), corpora lutea 



700- 



PCR CtNT iNCREASE = 



EXP WT- CONTROL WT 

 CONTROL WT. 



Xioo. 



TOTAL DOSE L4II. MILLIGRAMS DRY POWDER. 

 I I I 



UTERINE 0.12 

 OVARIAN OfiO 



024 

 120 



036 



L80 



0.48 

 2.40 



0.60 

 3.00 



Q72 



aeo 



Fig. 1 5. — The change in weight of the ovary and uterus of the mouse, in terms of 

 control weights, following various doses of follicle-stimulating hormone of "cas- 

 trate" urine. (From Levin and Tyndale, Endocrinology, 21, 619-28 [1937].) 



without uterine changes may appear after the injection of 

 gonadotropic extract (sheep pituitary extract, prolan) into 

 very young rabbits. No effects are produced in rabbits less 

 than 1.5-2 months old. 



Special efects of gonadotropic pituitary extracts or related 

 substances, i. The doctrine of antihormones. — Since the pub- 

 lication of reports by Collip and his collaborators indicating 



109 



