THE GONADOTROPIC HORMONES 



biological process undergoing acceleration as a result of an- 

 terior pituitary deficiency. Some dilute acid extracts of the 

 pars glandularis produced the same effect — suggesting that 



-^1.45 



.0^13.9 



o ^250 



9^25 



10 10 iO 



DAY^ AFTLR hYPOrHySCCTOMY 



3d 



Fig. 12. — Variations in the weight, total follicle-count, mean diameter of the 

 largest follicles, and per cent of vesicular follicles of the ovary of the rat following 

 hypophysectomy at an age of 28 days. Each point represents the mean of deter- 

 minations from 3 rats. (From Lane and Creep, Anat. Rec, 63, 139-46 [1935].) 



this action was due to inhibition of anterior pituitary secre- 

 tion. Lane and Creep (19.35) studied in detail the follicles 

 and the weight of the ovary of the rat hypophysectomized 

 at an age of 28 days. A graph summarizing their results is 

 reproduced in Figure 12. It will be noted that groups of 



[63] 



