THE PITUITARY BODY 



a marked hypophysial deficiency, probably because of the 

 disappearance of the chromophilic cells. Confirmatory ex- 

 periments in rats have been reported by McEuen, Selye, and 



Fig. 8. — The action of large doses of oestrone, administered over a period of 

 6 months, on the pituitary of the mouse. (From Cramer and Horning, Lancet, 

 230, 247-49 [1936].) /, Gross appearance of normal pituitary and optic nerves. 

 2, Pituitary of treated male mouse illustrating marked congestion of the pars glandu- 

 laris and compression of optic nerve. J, Photomicrograph of pars glandularis of 

 treated mouse (i") showing large hemorrhagic areas. 4, Photomicrograph of glandu- 

 laris of normal mouse at a slightly higher magnification than j. 



Collip (1936) and by Zondek (1936). It has not been con- 

 vincingly shown — as Zondek believed — that such pituitary 

 adenomata are produced much more readily in male than in 

 female rats. Lacassagne and Nyka (1937) concluded that the 



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