THE PITUITARY BODY 



tropic and adrenotropic hormone caused similar changes. 

 Iodine, KI, or diiodotyrosine were found to lessen the effects 

 (Franck, 1937). 



There has been some discussion as to the nature of the 

 changes in basophils in thyroidectomized as compared with 

 gonadectomized animals. Nelson and Hickman (1937), al- 

 though affirming that they could distinguish between the 

 alterations in basophils due to thyroidectomy or gonadec- 

 tomy, contended that the same basophils are affected by 

 either operation. They found that changes due to thyroidec- 

 tomy, except degranulation, could be corrected by the ad- 

 ministration of oestrone. Guyer and Claus (1937) believed 

 that the formation of vacuoles in the basophils is due to ac- 

 cumulation of secretion after gonadectomy, whereas after 

 thyroidectomy it is the result of cellular degeneration. Zeck- 

 wer (1937) particularly supports the view that the thy- 

 roidectomy and gonadectomy cells of the anterior pituitary 

 are different and can be identified morphologically. 



2. The adrenals. — Lippross (1936), using rats instead of 

 guinea pigs, found no significant changes in the morphology 

 of the pituitary — and adrenals and gonads — after the pro- 

 longed administration of adrenal cortical hormone or epin- 

 ephrine. Therefore, his findings did not confirm those of 

 Franck. 



The compensatory hypertrophy of an adrenal gland after 

 the extirpation of its mate depends chiefly upon the secretion 

 of an adrenal cortical stimulating hormone by the pars 

 glandularis. Zeckwer (1937-38), taking into account the 

 changes occurring in both adrenals following thyroidectomy 

 or gonadectomy, studied the effects of these operations on 

 compensatory adrenal hypertrophy in relation to the his- 

 tology of the pituitary. She concluded that the oxyphils, 

 which tend to disappear after thyroidectomy, do not secrete 

 the adrenotropic hormone. Also, this hormone was thought 

 not to be secreted by the thyroidectomy-cells or castra- 

 tion-cells, inasmuch as the degree of compensatory hyper- 



