THE PITUITARY BODY 



duced in response to sheep pituitary extract does not inhibit 

 the action of gonadotropic hormone secreted in situ by the 

 monkey's pars glandularis. 



The strongest evidence against antihormone-production as 

 a physiological mechanism is afforded by experiments with 

 animals living parabiotically, as has been emphasized re- 



CASTRATE 

 FEMALE 



HYPOPHYSECTOMIZED 

 FEMALE 



Body Weight 250 G 

 Thyroid 23 MG 



Adrenals 64 MG 

 Access 390 MG 



Ovaries 



Body Weight 180 G 

 Thyroid 13 MG 



Adrenals 16 MG 



Access 1350 MG 

 Ovaries AI6MG 



Fig. 1 6. — Diagram illustrating the ovarian changes which occur as a result of 

 parabiosis between a hypophysectomized rat with intact ovaries and a spayed rat 

 which otherwise is normal. No antihormone antagonizing gonadotropic hormone 

 is produced. (From DuShane, Levine, PfeifFer, and Witschi, Proc. Soc. Exp. 

 Biol. Med., 33, 339-45 [1935]-) 



peatedly both by the author and by other investigators (e.g., 

 Doisy, Martins, Witschi). Du Shane and others (1935) there- 

 fore consider antihormone formation a type of immune-body 

 reaction. Parabiosis between a spayed or castrated rat and a 

 normal or hypophysectomied female (e.g., ? 9 , ^ 9 , 

 ^ 9 h) is accompanied by a marked follicle-stimulating effect 

 of the gonadotropic hormone secreted principally by the 



1114] 



