CHAPTER VII 



THE INTERRELATIONSHIP BETWEEN THE PARS 

 GLANDULARIS AND THE ADRENAL GLANDS; 

 THE INFLUENCE OF THE PARS GLANDULARIS 

 ON THE METABOLISM OF CARBOHYDRATES, 

 LIPOIDS, PROTEINS, AND MINERALS (WITH RE- 

 MARKS ON THE PITUITARY-PARATHYROID IN- 

 TERRELATIONSHIP) 



NUMEROUS interrelationships between the anterior 

 pituitary and the adrenal glands have been sug- 

 gested or investigated in almost every field of in- 

 terest to the endocrinologist. Much of this work is discussed 

 elsewhere and, for complete references, the reader is referred 

 to the Index. The review in this section will be principally 

 confined to a discussion of the part taken by the anterior 

 pituitary in preserving the function of the adrenal cortex as 

 demonstrated by the morphology of that structure. The 

 important interrelationships affecting the metabolism of car- 

 bohydrates and fats are taken up in the sections dealing with 

 the metabolism of these foodstuffs. 



It is well known that the cortex of the adrenal glands 

 undergoes a pronounced atrophy after hypophysectomy, 

 whereas the medulla is affected scarcely at all. Likewise ex- 

 tracts of the anterior pituitary affect the cortex chiefly, if not 

 entirely. Therefore, almost all the discussion will refer to the 

 adrenal cortex. 



New observations oyi the effects of hypophysectomy or of an- 

 terior pituitary extract^ on the morphology of the adrenal glands. 

 — Adrenal cortical stimulating hormone is probably as wide- 



' No short, unobjectionable term to describe the hypothetical adrenal cortical 

 stimulating hormone has been devised. Such terms as "adrenotropic" and "corti- 

 cotropic" are undesirable from an etymological standpoint. 



I 198] 



