THE PITUITARY BODY 



in hypophysectomized animals from that in normal animals. 

 Shortly after food is withheld, however, a marked hypo- 

 glycemia appears in successfully operated animals. For ex- 

 ample, Russell (1936) found that the concentration of sugar 

 in the blood of young male rats, 3-4 weeks after hypophysec- 

 tomy, was reduced approximately 50 per cent after a fast of 8 

 hours, whereas the reduction occurring in normal rats was 

 only 20 per cent. If the fast was continued for 10 hours longer 

 (total 18 hours) a greater change then occurred in normal 



NORMAL 



1 HYPOPHYSECTOMIZED 



■ 1 1 1 ' I M ' 



!0 I 30 I -^0 I so I 60 



J_l 



»0 I 90 I 100 I IIP I 120 I 130 I HO | 150 



BLOOO SUGAR MG. PER lOOCC.OF BLOOD 



Fig. 23. — The concentrations of sugar in the blood of normal and hypophysecto- 

 mized monkeys in relation to their frequency. The monkeys were first starved i6- 

 18 hours. (From Smith, Dotti, Tyndale, and Engle, Proc. Soc. Exp. Biol. Med., 34, 



247-49 [1936].) 



rats (total reduction, 32 per cent) than in hypophysecto- 

 mized animals (total reduction, 54 per cent). The results of 

 the withdrawal of food are similar in the rabbit (Cope, 1937) 

 and monkey (Smith and others, 1936). Figure 23 illustrates 

 the distribution of concentrations of sugar in the blood of 

 normal and hypophysectomized monkeys, as determined by 

 Smith, Dotti, Tyndale, and Engle after the animals had been 

 fasted for 16-18 hours. The concentration of sugar in the 

 blood of partially hypophysectomized monkeys was found 

 to lie (87 + 2.7^ mg. per cent) between that of normal 

 monkeys (iio + 2.0^ mg. per cent) and that of hypophysec- 



' Standard error of the mean. 



206 



