THE PITUITARY BODY 



unlike the normal, cannot form carbohydrate from fat/^ 

 Ketonuria does not appear readily in hypophysectomized- 

 depancreatized dogs even in the presence of hyperglycemia 

 and glycosuria. The authors concluded that glucose can be 

 endogenously derived only from carbohydrate and protein 

 after hypophysectomy. Crandall and Cherry (1937) likewise 



TABLE 6 



Carbohydrate Metabolism in Normal and in 



HVPOPHYSECTOMIZED RaTS* 



* From Bennett, Proc. Soc. Exp. Biol. Med., 34, 277-79 (1936). 



performed experiments with dogs and believed that their re- 

 sults indicated that the formation of glucose from one amino- 

 acid, glycine, is not prevented by hypophysectomy. The 

 technic of their experiments is described in the section 

 dealing with the effects of insulin.'^ 



The recent experimental work so far reviewed, as well as 



'i However, even in normal dogs, it is not generally believed that proof of the 

 formation of carbohydrate from fat, other than glycerol, is available. 



'■•According to Schott, Samuels, and Ball (1937), the Walker tumor No. 256 

 in male rats contains significantly more glyocgen (but grows more slowly) in hy- 

 pophysectomized than in normal rats. The amount of glycogen in the tumor of rats 

 was: (i) 4 hours after feeding: normal, 0.026 per cent; hypophysectomized, 0.046 

 per cent, and (2) on high caloric diet: normal, 0.058 per cent; hypophysectomized, 

 0.186 per cent. 



[210] 



