THE PITUITARY BODY 



daily affected neither the hyperglycemia nor the glycosuria 

 due to pancreatectomy. Depancreatized monkeys survived 

 even several months without insulin and irrespective of oes- 

 trin treatment. The depancreatized monkey resembled the 

 dog or cat after removal of the pancreas and adrenals or 

 of the pancreas and hypophysis. 



The effects of extracts of the pars glandularis on the metabo- 

 lism of carbohydrates. — Young's experiments in dogs (1937) 



5 10 15 20 25 30 35 40 

 Days oFter pituitary injections wci-e begun 



Fig. 24. — Diagram illustrating the production of a condition resembling dia- 

 betes mellitus by repeated injections of anterior pituitary into a dog. The numerals 

 between arrows refer to the grams of fresh anterior pituitary of the ox used to pre- 

 pare the extract injected daily until the next larger amount was used. Injections 

 were stopped on the twenty-sixth day. (From Young, Lancet, 233, 372-74 [1937].) 



indicate that anterior pituitary extract can be truly diabeto- 

 genic. Figures 24 and 25 are reproduced from his report. 

 xAfter repeated injections of anterior pituitary extract were 

 stopped, a permanent diabetes mellitus appeared in 2 dogs. 

 However, the animals remained vigorous without the admin- 

 istration of insulin, and in one there was no loss of weight. 

 If insulin was injected to prevent almost entirely the excre- 

 tion of glucose, it appeared that more was required (4.4 units 



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