PARS GLANDULARIS AND METABOLISM 



per kg. body-weight per day) than in the depancreatized 

 dog. However, Young emphasizes that this is only his 

 impression, xAmong other general observations are those of 

 Etcheverry (1937) and Foglia and others (1937), Etcheverry 

 concluded that bilateral supra-diaphragmatic vagotomy with 

 or without removal of the abdominal sympathetics does not 

 modify the course of diabetes caused either by pancreatec- 



!.,§ 2000 



1$ 1000 - Urine vol. 



275 280 285 290 295 300 305 310 

 Days oFter pituitary injections were begun. 



Fig. 25. — Continuation of Figure 24 after a long interval not shown in the dia- 

 grams. The daily injection of 60 units of insulin was begun at the first arrow and 

 stopped at the second arrow. Death occurred on day 309. (From Young, Lancet, 

 233, 372-74 [1937]-) 



tomy or by the injection of anterior pituitary extract, Foglia 

 and others injected crude anterior pituitary extract into dogs 

 with diabetes following pancreatectomy. The extract short- 

 ened survival time, increased the formation of acetone bodies 

 and the deposition of lipoids in the liver, and antagonized 

 the action of insulin. 



The effects of anterior pituitary extract in experiments of 

 short duration were observed in normal and hypophysecto- 



[223] 



