THE PITUITARY BODY 



mann, 1936; Taubenhaus, 1936).-'^ If a ketogenic pituitary 

 extract be injected repeatedly, the animal becomes refractory 

 to this effect (Bennett, 1937). 



Teilum (1937) attributes to the pituitary the hyper- 

 cholesterolemia which he observed invariably in gonadec- 

 tomized persons or patients with hypogonadism. He offers 

 no satisfactory evidence for this interpretation. If we accept 

 the data of Cioglia and Tore (1936), gonadectomy is followed 

 by hypocholesterolemia (rabbit). These authors observed 

 hypercholesterolemia after the administration of prolan or 

 pituitary gonadotropic hormone. 



THE METABOLISM OF PROTEIN AND SOME NON-PROTEIN 



NITROGENOUS COMPOUNDS IN RELATION TO 



THE ANTERIOR PITUITARY 



The metabolism of protein in relation to the pituitary body. — 

 In addition to references in other chapters, there remain a 

 few general reports on the metabolism of protein. Gaebler 

 and Price (1937) studied the action of single large doses of 

 anterior pituitary extract (with growth-promoting proper- 

 ties) on the metabolism of protein in dogs. The authors 

 found that a fall in the rate of excretion of N, S, and phos- 

 phate was associated with a rise in weight. At the same time 

 the ratio of N to S increased and more N was retained. All 

 these changes are similar to those occurring when synthesis 

 of protein is in progress and suggest that the extract had, in 

 fact, brought about an increased rate of protein synthesis. •'•' 



^' The obesity of a patient with Cushing's syndrome was considered by Freyberg 

 and Newburgh (1936) not to be caused by any unusual metabolic derangement, 

 because loss of weight due to undernutrition took place exactly as in normal 

 persons. 



33 See also the report of Paschkis and Schwoner (1937), who investigated the 

 action of commercial anterior pituitary extracts on the level of the amino acids in 

 the blood of patients who had been given gelatine by mouth. 



Binet, Kepinov, and Weller (1935) published determinations of reduced and total 

 glutathione in the liver, thyroid, and testis of normal and hypophysectomized dogs. 

 Hypophysial deficiency was found to be accompanied by reductions in the concen- 

 tration of glutathione in all three tissues; the most marked reduction occurred 

 in the thyroid, the least in the testis. 



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