THE PITUITARY BODY 



of great value in the treatment of Simmonds' disease; he also 

 described the successful transplantation of calf pituitary into 

 the peritoneal cavity of the rabbit. 



According to Gagyi (1936), who performed titrations with 

 2,6 dichlorophenolindophenol, the pars neuralis (contrary to 

 Giroud and Leblond) contains about three times as much 

 ascorbic acid as the pars buccalis in terms of concentration 

 (pars neuralis 7.2 and the pars glandularis-pars intermedia 

 2.3 mg. per gm). Also he stated that the gland of immature 

 animals, especially females more than males, contains a 

 higher concentration of the vitamin than the gland of adults. 

 The observations were made in guinea pigs. Two other re- 

 ports refer to constituents of the pituitary. Regnier (1936) 

 found that sulfonal (diethylsulfonmethane) was deposited in 

 the pars glandularis to a greater extent than in any other 

 tissue after the drug had been administered by mouth to a 

 horse (40 gm. to a horse weighing 450 kg.). The tissues con- 

 taining the highest concentrations of this hypnotic, expressed 

 as milligrams per 100 gm., were: pars glandularis, 750; 

 adrenals, 426; pars posterior, 200; blood, 29.4. The brain con- 

 tained 7.8 mg. per 100 gm. It is extremely unlikely that the 

 presence of bromine in the pituitary body has any signifi- 

 cance. Dixon's recent report (1935) indicated that the pitui- 

 tary of the normal pig contains about 0.27 mg. of Br per 100 

 gm. of fresh tissue. As in other organs the ratio of Br to CI 

 roughly corresponded to what was probably the ratio of these 

 elements in the diet. According to Moruzzi and Guareschi 

 (1936), the fresh pituitary of the ox and of man contains re- 

 spectively about I or about 0.6 mg. of Br per 100 gm. 



SUMMARY 



The morphological and functional maintenance of the cor- 

 tex of the adrenal glands depends upon secretion (s) of the 

 pars glandularis. (The medulla of the adrenal gland may 

 have important indirect interrelationships with the anterior 

 pituitary ; its direct dependence on the anterior pituitary prob- 



[238] 



