THE PITUITARY BODY 



"was not controlled by injections of pituitrin"). The report 

 of Adlersberg and Friedmann (1935) deals with changes in 

 the metabolism of water, under various conditions, in pa- 

 tients with lesions of the mesencephalon or diencephalon or 

 both. In some instances the response to posterior-lobe ex- 

 tract was clearly diminished. Keller, Noble, and Hamilton 

 (1936) stated that a "complete" separation of the pituitary 

 from the hypothalamus (including "the greater portion of the 

 infundibulum") in the dog is not followed by any increased 

 water or food consumption by the animals. More recently, 

 Keller and Hamilton (1937) observed complete degeneration 

 of the nerve fibers in the pars neuralis as a result of lesions 

 of the tuber cinereum in 7 cats. In 4 of the cats there was no 

 diabetes insipidus; the authors concluded that degeneration 

 of the nerves of the pars neuralis — contrary to the views of 

 Ranson and his colleagues — is not necessarily accompanied 

 or followed by diabetes insipidus. Other data of less recent 

 origin, some of which also can be interpreted as opposing the 

 beliefs of Fisher, Ingram, and Ranson, have been reviewed 

 already (van Dyke, 1936). 



3. To what extent does diabetes insipidus depend upon a func- 

 tioning pars glandularis? — The hypothesis of von Hann, sup- 

 ported by the later experimental work of Richter, has already 

 been discussed (pp. 276-77). It is proposed here to review 

 briefly a number of recent communications bearing on this 

 question. 



In a few reports diabetes insipidus — or the secretion of an 

 increased volume of urine — has been observed in completely 

 hypophysectomized animals (toad: Pasqualini, 1935; rat:' 

 Dodds, Noble, and Williams, 1937; dog: Page and Sweet, 

 Reichert and Dandy, 1936). On the other hand, Buratschew- 

 ski and Rappoport (1936) found that the metabolism of salt 

 and water in the dog was not disturbed by either hypophy- 

 sectomy or the removal of the pars neuralis. Such data con- 

 tradict most of the recent findings of others. 



"• See also Sandberg, Perla, and Holly (1937). 



[282] 



