THE ENDOC'RINAL ORGANS 



335 



when, as the result of tumorous enlargement, anterior lobe secretion is 

 increased, a local growth of bone, sometimes asymmetrical, may occur. 

 Such cases of acromegaly are not infrequent. Experiments demonstrate 

 that deficiency of anterior lobe hormone in young animals results in failure 

 of sexual development and atrophy of the sex glands. 



ENDOCRINE INTERRELATIONS 



POSTERIOR LOBE 0>ITRESSIN AND PITOCIN) PANCREATOTROPIC. KETOGENIC . PARATHYREOTROPIC 



4TH DAY OF MENSTRUAL CYCLE WTH DAY 28TH DAY 4TH DAY 



Fig. 297. — A diagram illustrating the complex interrelations of the endocrine 

 organs. The multiplicity of pituitary influences is only partially indicated. For the 

 sake of clearness the diagram over simplifies the relations. The pancreatropic, keto- 

 genic, and parathyreotropic factors are not thoroughly understood. (Adapted from 

 Therapeutic Notes through courtesy of Parke, Davis & Company.) 



The pituitary gland has a double origin. The anterior lobe comes 

 from an ectodermal sac, Rathke's pouch (hypophysis), in the roof of the 

 mouth, while the posterior lobe is formed as an outgrowth of the base of 

 the diencephalon. The posterior end of Rathke's pouch comes into 

 contact with the infundibular outgrowth from the base of the brain. As 



