IMMUNIZATION OF STRESSED ANIMALS 



100 I 





0.1 



• OU 



'A. * 



"♦----< 



"~-6^ 



-->^^ 



L_^^ \ L 



10 20 40 70 



70 90 110 150 190 230 270 310 350 

 DAYS AFTER LAST INJECTION 



Figure 3. Semilog plot of retention in perfused liver tissue of single injection of 50 mg 

 of S"^^SA (A); single injection of 50 mgS'^^KLH (B) ; 9 injections of 10 mg each of S^^bsA 

 (C); 9 injections of 10 mg each of S"^^KLH (D). Each point represents average value for 

 3-5 rabbits. Center of circles indicates mean of distribution, indicated by the arrows. 

 (From Garvey and Campbell, Jour. Exp. Med., 10 5, 361. 1957.) 



animals at a higher temperature and at sea level. Apparently 

 the answer involved hypersecretion of corticosteroids. 



There are many practical problems dealing with the relation 

 of cold stress of adaptation to immune mechanisms. Many factors 

 other than metabolism must be involved. For example, skin tests 

 may depend to some extent on the state of peripheral capillary cir- 

 culation, and immune responses in general will depend upon the pre- 

 vious history of the subject. In finishing, I wish to emphasize the 

 importance of Dr. Viereck's statement; namely, that the physio- 

 logical state of an animal must be determined and not assumed. 

 Furthermore, there is a great difference between stress, adaptation, 

 and normal states. 



85 



