ENTEROVIRUSES IN ALASKA 



SULKIN: Yes. In the report*^ describing the immunologic 

 classification of polioviruses into three distinct types it was 

 indicated that they did not share a common antigen. However, 

 other studies, such as that just referred to by Sabin, would 

 indicate that common antigens do exist. A soluble complement- 

 fixing antigen crosses in the GF test with heterotypic polio- 

 myelitis antibodies. 



MET CALF: There are serum neutralization tests. I wonder 

 if there is any danger of a crossing here which you might miss 

 interpreting? 



REINHARD: They were remarkably specific; however, in a 

 population cross section study like this, in the adult group, 

 where antibodies against all three types are present, it would 

 be difficult to unscramble the Type antibody reactions. But 

 note, however, the early prevalence of Type 2 reactions and 

 the later rise of Types 1 and 3 antibodies. The peak prevalence 

 of Type 3 antibody was hinted around twenty some years of age. 

 Type 1 was most prevalent at age twenty or so, as I remem- 

 ber. Of course, the peak prevelance of Type 2 antibodies was 

 in children. 



SULKIN: Isn't this quite similar to the situation reported 

 several years ago by Hektoen and Boor when they studied simul- 

 taneous multiple immunization of rabbits with a variety of anti- 

 gens? I recall there was a remarkable response to a blunder- 

 buss vaccine containing as many as 35 antigens, although some 

 "crowding out" effect was observed, that is, failure of antibody 

 to develop to one or more antigens included in the vaccine. This 

 may account, at least in part, for the observation to which you 

 refer, 



REINHARD: Yes. 



MARROW: I should like to make one observation as a physician; 



3 National Foundation Committee. 1951. Am. J. Hyg. 54: 191-204. 



4 J. Infect. Dis. 48: 588-594. 1931. 



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