ENTEROVIRUSES IN ALASKA 



the statements that are made are not based on thoroughly tested 

 data? 



SULKIN: Not exactly. Actually, while there might be a per- 

 sistence of the attenuated strain, the concept is that the very 

 presence of the attenuated strain would prevent wild t5T)e virus 

 from invading the host. So, you are dealing with two different 

 agents; one interfering with the invasion of the host by the other. 



REINHARD: You are speaking about biological interference? 



SULKIN: Yes, this is precisely the mechanism which, it is 

 hoped, will operate as a result of oral immunization, 



MARCUS: And when the excretion of the avirulent strain 

 ceases, you would say, then, the individual is susceptible once 

 again? 



WALKER: He is considerably more resistant to infection, 

 even in the gut. 



MARCUS: Is this true of the other enteroviruses? 



WALKER: They can be reinfected with other antigenic strains, 

 but they must be more resistant. 



MITCHELL: If you had virus particles of the so-called attenu- 

 ating type and the so-called wild type, equal in number, and 

 you placed them before the susceptible cells, which would the 

 cell choose? Would it choose the attenuated, or is the attenuated 

 virus more aggressive than the wild type? 



SULKIN: The point is, by introducing attenuated virus, that 

 attenuated virus will replicate in the most desirable part of 

 the body for that organism, which happens to be the alimentary 

 canal, so that you no longer have equal numbers. 



MITCHELL: It is already there and usually has the advan- 

 tage of an increased population. A good big man can always whip 

 a small man. 



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