MC CLAUGHRY 



They all survived because they were children. Their natural 

 homeostasis was very kind to us. 



BERRY: How much adrenal response is there in these patients? 



BLAIR: The adrenal response is reduced. Again, this is the 

 difference between induced hypothermia and cold exposure. This 

 is related, of course, to the type of anesthesia used. These people, 

 you know, are all anesthetized. If a barbiturate anesthesia is 

 used, the response of the adrenals is reduced tremenduously. 

 Ether anesthesia invokes an increased response for a period 

 of time, but when the patient and the animal are cooled, then 

 the circulating cortico steroid and catecholamines are very 

 much lowered. Hypothermia allays stress response, 



BERRY: In other words, hypothermia is almost anti-stress? 



BLAIR: That is correct, as opposed to cold exposure, 



BERRY: I think these are very important distinctions that we 

 should keep in mind, 



MITCHELL: Dr, Blair, where are your prime heat sinks 

 for retaining heat calories in these bodies once you start cooling? 

 You take them down with cooling to 20° C and you maintain this 

 for quite a time. You are now ready to work and you have some 

 tissues there that are rather tremendous heat sinks. They re- 

 main warmer, let's say, and then if you move past that to these 

 colder temperatures, do you overcome the ability of that tis- 

 sue to resist, or do you make it more susceptible, and wherein 

 do you get these infectious processes originally? I am trying 

 to figure out how you approach this, 



BLAIR: Are you referring to the instances of cooling either 

 animals or patients down to profound levels in the absence of 

 infections to begin with? Is this what you mean? 



MITCHELL: Yes. 



BLAIR: First of all, with regard to heat production during 



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