IMMUNE RESPONSE IN COLD EXPOSURE 



16. Sutherland, G. Bonar, and Dan H. Campbell. 1956. Cold adapted 



animals. I, Changes in blood clotting and electrophoretic 

 properties of rabbit plasma. Proc, Soc. Exp. Biol. Med. 

 91: 64-67. 



17. Sutherland, G. Bonar, Ignatius L.Trapani,andDanH. Campbell. 



1958. Cold adapted animals. II, Changes in the circulating 

 plasma proteins and formed elements of rabbit blood under 

 various degrees of cold stress. J. App. Physiol. 12: 367-372. 



18. Trapani, Ignatius L,, and Dan H. Campbell. 19 59. Passive 



antibody decay in rabbits under cold or altitude stress. J. 

 App. Physiol. 14: 424-426. 



19. Trapani, Ignatius L. 1960. Cold exposure and the immune 



response. Symposium on cold acclimation. Federation Proc. 

 19: Supplement No. 5, 109-114. 



20. Uriel, J., and P. Grabar. 1956. Bull. Soc. Chim. Biol. 38: 



1253-1269, 



DISCUSSION 



BLAIR: Is cold responsible for the changes that have been 

 observed both with regard to the antibody turnover rates, and 

 also with regard to the immune- electrophoretic studies, or is 

 cold simply a stimulus? In other words, could not the same 

 situation be produced in the laboratory with stimuli other than 

 temperature stimuli, but resulting in experimental preparations 

 metabolically, at least, similar to that induced by cold? In other 

 words, is not cold just a non-specific stimulus, or is cold really 

 responsible for these changes? 



TRAPANI: Are you asking about the effect of temperature 

 at the cellular level? 



129 



