NORTHEY 

 SULKIN: I am not sure. 



CAMPBELL: I suspect you might get a difference in the ratio 

 or distribution in some proteins that might be there in minor 

 amounts. Most of it is the ratio. Instead of being five per cent 

 or ten per cent of the total proteins, it may go up to twelve 

 or fifteen per cent. Now, under stress conditions, I cannot see 

 that anything can happen within an hour or two or even with- 

 in a few hours, other than changes in fluid balance perhaps ; 

 then you get changes in protein like the hibernating squirrel. 

 It looks like its got a high protein concentration, which it has, 

 but the total amount of protein may be actually the same as a 

 normal animal. I don't know what the blood volume was because 

 I didn't measure that. 



PREVITE: I agree with what Dr. Sulkin stated a few minutes 

 ago. There is a tremendous difference between hibernation and 

 induced hypothermia. Dr. Lyman at Harvard has just emphasized 

 this in a review on hibernation.^ In answer to Dr. Mitchell's 

 question about stress, Dr. Cardy,^ of the University of Penn- 

 sylvania, noted that whether or not an animal is stressed de- 

 pends upon the host and the conditions of the experiment. 



MITCHELL: And the interpretation of the investigator in whether 

 or not he is going to measure it by lowered temperature or the 

 presence of this or the presence of that. 



REINHARD: To reply to Dr. Mitchell, there is one more im- 

 portant factor. I wish more people would do comparative work 

 using various species, because no one animal is exactly rele- 

 vant to man, and they do differ in basic physiology, especially 

 the gastroenterological portion of it. 



McCLAUGHRY: I think it might be well to keep in mind here 

 the distinction between the physiological function of protein 

 metabolism as it might be reflected by the antigen- antibody 



1 Lyman, C. P. 1961. Circulation XXIV. 



2 Hardy, J, D. 1961. Physiol. Rev. 



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