TUNEVALL AND LINDNER 



Total N: 102 ± 7.6 

 Total H: 220 ± 11.5 



Diff. 118. t = 8.09. dF 50. P< 0.001 



Figure 5. Survival times in normothermic versus hypothermic mice given one 

 MLE>ioo of staphylococcal toxin. Hypothermia induced about 5 hours before the toxin 

 injection. (N ■ normothermic. H ■ hypothermic). 



the work on tetanus toxin. In order to establish suitable experi- 

 mental conditions, a number of neutralization tests were first 

 set up in normothermic mice given only the pretreatment. The 

 results are reported in Fig. 6 and Fig. 7. 



As the number of mice was small and as the results emanate 

 from several experiments, no statistical treatment has been done, 

 but generally, there was a good correlation between the length 

 of the toxin- antitoxin interval and the survival times. Essentially, 

 the experiments differed in one respect only; in one group, the anti- 

 toxin dose was increased from one to four neutralizing units, and 

 the results of this experiment are reported in Fig. 6 and Fig. 7. 



142 



