HYPOTHERMIA AND BACTERIAL TOXINS 



CAMPBELL: I was thinking of the situation in which the 

 antibodies are already there and they are less operative. I do 

 not know the mechanism on neutralization, but you do have stress 

 conditions in which you can reduce shock, particularly in mice, 

 by injecting cortico steroid. If you inject it ten or fifteen min- 

 utes before you inject antigen, you can reduce the hypersensitivity 

 of the reaction. 



BERRY: Dr. Previte did some experiments with staphylococci. 



PREVITE: Yes, that was part of a study on cold exposure. 

 However, since the experiments were of short duration, and 

 since rectal temperatures of staphylococcus toxin injected ani- 

 mals were not measured, and hypothermia was not induced, the 

 results are probably not applicable to Dr. Tunevall's findings. 



BERRY: No, they are not directly so, but there was no effect 

 of cold exposure under your conditions? 



PREVITE: No, because the number of animals used was not 

 large enough. However, the results did indicate that a signifi- 

 cant effect would have been demonstrable with a larger number 

 of mice. 



MITCHELL: Saint Patrick did such a good job over in Ireland, 

 but would the same mechanisms that you are talking about rela- 

 tive to h5T3othermia, and with your so-called antitoxin, work 

 also for venoms of snakes? 



BERRY: You are asking Dr. Tunevall? 



MITCHELL: Yes. 



ANDRE WES: He didn't know about Saint Patrick. 



MITCHELL: Saint Patrick did a good job of cleaning up Ire- 

 land of snakes for the poor. Actually, what I am talking about 

 is whether or not the mechanism you have described, say, for 

 staph- toxin, and for one of your other toxins, works equally 

 well for venoms of what we call our rattle snake, or in our 



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