Figures 139-149. — Developmental stages of monocytes as found in the circulating blood, also abnormal 



cells and artifacts. 2,470 X. 



Figures 1.39-142: Developnienla! stages toilh intensely 

 stained nuclei, ranging from leplochromatic to pachy- 

 chromatic type. 



1.39 The young amoeboid cell of the monocyte series; 

 possibly a monoblast. A nucleolus is faintly shown. 



140 Amoeboid monocyte with both azurophilic granules 

 and magenta bodies. 



141 A round young monocyte. 



142 A young monocyte with a rounded nucleus. The 

 cell has a well-developed Hof, and a concentration of 

 azurophilic granules around the periphery. 



Figures 143, 144: Developmental stages with lightly stained 

 nuclei. 



143 Amoeboid monocyte, more differentiated than the 

 blast stage. 



144 Nearly mature monocyte. The contents of the Hof 

 vacuoles are slightly stained. 



Figures 145-147: Abnormal monocytes. 



145 The accumulation of basophilic granules around 

 the periphery of the cell is not typical. The faint 

 reddish tinge of the cytoplasm is suggestive of early 

 autolysis. 



146 A monocyte definitely undergoing autolysis. 



147 Some Hof vacuoles have become abnormally large. 

 Vacuolar content stains a light orange color. 



Figures 148, 149: Technic artifacts. Smudged monocytes. 



148 .\ monocyte in which the cytosome, but not the 

 nucleus, has broken. 



149 Identification of this as a squashed monocyte 

 nucleus is b.ased on the fact that this slide contained 

 many such cells with transitional stages from normal 

 intact monocytes to this type of large basophilic 

 mass. 



60 



