56 



PHYSIOLOGICAL EEGULATIONS 



rate of output of water in recovery from water excess. But ad- 

 ministering the drug novasurol (D) seems to remove the effect of 

 phosphorus treatment. 



Physical exercise of running prevents or reduces the usual 

 response to water introduction by stomach (Rydin and Verney, 

 '38). This inhibition of diuresis may intervene at any time after 

 diuresis has begun, and may outlast the exercise by various lengths 

 of time. 



+4 



12 3 4, 



Hours 

 Fig. 36. Course of sensible water load after single ingestions of water by stomach. 

 Each of four individuals is tested once in each series. Data of Abe ( '31c). A, in control 

 state; B, given novasurol intramuscularly; C, treated with phosphorus; D, treated with 

 novasurol and phosphorus. 



The general conclusion is that many regimes give rise to physio- 

 logical states that modify the recovery of water balance. 



d. Various solutions may be substituted for water to constitute 

 positive loads. Given by stomach, such solutions induce almost 

 any degree of polyuria and oliguria, according to the solute, its 

 concentration and amount (Chanutin et al., '24; Rioch, '30; Mel- 

 ville, '36 ; Kaunitz, '37). Given by vein the return is no more com- 

 plete (D, fig. 37) than when water is substituted (fig. 30). Super- 

 imposed upon diverse negative loads of water (fig. 37) almost no 



