PREFACE Vll 



I wish to acknowledge the generous encouragement of the late 

 Professor L. J. Henderson, who furnished the environment for the 

 inception of this specific investigation. He took the trouble to 

 read the manuscript shortly before his untimely death. Possibly 

 years ago he and the late Professor J. S. Haldane unwittingly 

 implanted a curiosity about the regulative aspects of physiology. 

 I am grateful for the comradeship of my students who have shared 

 in the laboratory studies concerning water and heat metabolism. 



Material aid was accorded the prosecution of this work through 

 various administrative officers of the University of Rochester. 

 The publication is made possible by the School of Medicine and 

 Dentistry of the University. 



E. F. Adolph 

 October, 1942 



