WATER RELATIONS OF MAE" 



91 



the loads administered. How to obtain one or the other result at 

 will is not known; a priming ingestion 3 hours previous to the test 

 somewhat augments the return, however. 



Initial rates at which excess water is eliminated increase with 

 water load up to a maximal rate (fig. 52). The later rates are 



Hours 



Fig. 51. Course of sensible water load (% of Bo) after a single ingestion. Indi- 

 viduals with two types of hepatic disease (jaundices) were compared with control indi- 

 viduals. Only in one, obstructive jaundice, was the excretion of excess water in urine 

 significantly retarded. A, 12 control individuals; B, 7 patients with diagnosis of ca- 

 tarrhal jaundice; C, 4 patients with diagnosis of obstructive jaundice with cancer of 

 the bile duct. Data of Abe ('31a). 



more rapid, and still later rates decline. Once the rates of elimi- 

 nation have begun to decrease (fig. 53), the rates are significantly 

 independent of time and are related to load. 



Net velocity quotients (1/At) are highest at moderate loads 

 (about +1% of Bo). The maximal values attained indicate what 



