222 



PHYSIOLOGICAL EEGULATIONS 



and loss of intestinal juice (Herrin, '35). In them also negative 

 dilutions of serum-protein nitrogen, of blood hemoglobin, and of 

 other measures, are found. But the relative values obtained among 

 several sorts of dilution are not like those here reported. 



Volumes of distribution of the water load (or should they be 

 termed dilutions of distribution?) allowably may be computed from 

 the increments of some dilution, such as refractive index of plasma 

 (fig. 126). They show that just after a load is administered, time 

 is a large factor, in both positive and negative water loads. After 

 a sufficient period (one hour) the volumes of distribution of water 

 are all much less than 100 per cent of the body (fig. 118) ; this fact 



+10 



-10 



Fig. 126. Increment in dilution of plasma as reciprocal of excess refractive index 

 (% of initial) in relation to total water load (% of Bq). A supplementary grid shows 

 volumes of distribution of the added water in plasma, as % of the body weight. The 

 course of simultaneous points is traced in averages of three types of test. One hour 

 after ingestion began is marked (/). B, ten successive administrations of water by 

 stomach, 6 tests from figure 117. S, single administration of water by stomach, 3 tests 

 from figure 116. T, single voluntary ingestion of water by mouth, 4 tests from figure 

 120. 



is confirmed by fewer like data of Abe ( '31a) and of Hatafuku 

 ('33a). It indicates again that the plasma undergoes somewhat 

 more change than the body as a whole ; the positive increments of 

 water being apparently distributed through a volume less than that 

 occupied by water already present. 



In the tests represented in table 24 some nine quantities are 

 measured simultaneously. By correlating these two at a time a 

 fairly complete study is accomplished; though triple and higher 

 multiple correlations still remain open. Of the bi-correlations, only 

 rate of water output in relation to dilution is shown graphically 



