DIVERSE COMPOXEXTS 



333 



cose is 50% of Bo (Wierzuchowski, '36) under all the conditions 

 measured. Equally informing, and perhaps more direct, would be 

 to correlate the concentration of reducing substances found in 

 whole blood with the rate of its change ; then, however, the partition 

 of disposals would require further assumptions before common 

 dimensions would be shared. 



Glucose was infused at constant rates, five of which are repre- 

 sented in figure 163. At the smaller rates, loss equals gain after 



Hours 



Fig. 163. Glucose load (increment in gm. of glucose/kilogram of Bo) in relation 

 to time. Glucose was infused intravenously for 6 hours at constant rates that are in- 

 dicated (in gm./kg. hr.) hx numerals on each curve. Loads are computed from blood 

 <:oncentrations assuming a uniform volume of distribution of 50% of Bo. Data of 

 Wierzuchowski ('36, p. 322). 



the first hour, so that loads are stationary. But at higher rates 

 glucose accumulates. The rate of total loss (disposal) of glucose 

 remains steady after the first hour (fig. 164) ; but at infusion rates 

 of 8 and 9 gm./kg. hr. the rate of loss does not equal the rate of 

 .gain. The loss is partly in urine (fig. 165), though almost none is 

 so lost at the lower rates of administration. 



"When rates of loss are correlated with loads (fig. 166), it is evi- 

 dent that output attains a limiting rate when 8 gm./kg. hr. are 



