DIVERSE COMPONENTS 



337 



Fig. 167. Glucose velocity quotient (l/hour), in relation to time after continuous 

 infusion of glucose began, at rates indicated by numerals (in gm./kg. hr.). Data of 

 Wierzuchowski ('36), from figures 163 and 164. 



hour the state is a steady one (fig. 168), the velocity quotient for 

 total glucose disposal is independent of time; and this quotient 

 diminishes progressively with load to a much greater extent than 

 the velocity quotient for water disposal. 



While rates of excretion of glucose increase with loads (fig. 

 166), the rates of synthesis and of oxidation are independent of 

 loads above 2 gm./kg. of body weight. The patterns of these paths 

 stand in sharp contrast; for here are two paths for disposal (rate 

 of synthesis, rate of oxidation) that do not vary with load, while 

 another (renal excretion) is mainly dependent on it. The latter is 

 such that clearance from blood, and velocity quotient, are approxi- 



Glucose Load — qm/kg. 



Fig. 168. Glucose velocity quotient (l/hour) for net disposal, in relation to glucose 

 load. Dog. The triangles represent the period 1.5 to 3.5 hours, and the circles 3.5 

 to 5.5 hours after continuous glucose infusion began. Same data of Wierzuchowski 

 ('36). 



