338 



PHYSIOLOGICAL, REGULATIONS 



mately constant at all loads above 1 gm./kg. That load corresponds 

 to what was once termed the "assimilation limit." 



Some parallel data have been obtained by the entirely independ- 

 ent method of analyzing total carbohydrate in the body (fig. 169). 

 Many points of technical difference may be noted between this set 

 of tests and the previous ones ; this set nevertheless indicates the 

 slowness of the exchanges of total carbohydrate, especially with 

 excretion blocked, as compared with those of glucose alone. Re- 

 moval of pancreas does not limit the "ability" to utilize carbo- 

 hydrate, but limits those high rates of utilization to greater loads. 



0.8 



1 



o 

 o 



cc 



.Glucose Load~ 



qm/kg.of Body 



8 



\Z 



Blood Sugar Concentration 

 qm/l. of Blood 

 Fig. 169. Kate of carbohydrate loss (in gm./kg. hr.) in relation to mean glucose 

 load. Dog under nembutal anesthesia after "evisceration," and privation of food for 

 3 previous days. Glucose was infused by vein continuously for 2 hours before the test 

 began and during 4 hours in which the carbohydrate disposal was being measured. Each 

 point represents one individual, samples of whose tissues were analyzed before and after 

 the 4-hour period. Note that ordinate scale is ten times that of figure 166. Here the 

 loss is probably all by oxidation. N, control; P, pancreas also removed. Data of 

 Soskin and Levine ('37). 



Deficits of glucose are induced by injections of insulin (fig. 170). 

 Thereafter glucose is gained (net) and more slowly as zero load is 

 approached. Absence of medullary portions of the adrenal glands 

 interferes but little with the course of recovery from deficits of 

 glucose. The slower exchange after high doses of insulin may be 

 accredited to persisting action of this agent in tending to remove 



