CONTENTS 



PAGE 



Chairman's introductory address. Rate-limiting factors 

 in cell respiration 



by Sir Hans Krebs ....... 1 



Discussion : Chance, Dickens, de Duve, Greville, Hinshel- 

 wooD, Krebs, Lipmann, JNIagasanik, McIlwain, Pardee, 

 Potter, Racker, Siekevitz, Slater . . . . 11 



On the meaning of intracellular structure for metabolic 

 regulation 



by P. Siekevitz ....... 17 



Discussion: Aldridge, Bartley, Chance, King, Lipmann, 



Lynen, Potter, Racker, Siekevitz .... 45 



Some topographical aspects of the regulation of cell 

 metabolism 



by C. DE Duve ........ 50 



Discussion : Chance, Coxon, de Duve, Estabrook, Greville, 



Lehninger, Potter, Siekevitz, Slater ... 53 



Control of rate of intracellular respiration 



by E. C. Slater and W. C. Hulsmann ... 58 



Discussion: Chance, Hess, Holton, Krebs, Lehninger, 



Lynen, Potter, Racker, Siekevitz, Slater ... 83 



Quantitative aspects of the control of oxygen utilization 



by B. Chance ........ 91 



Discussion: Aldridge, Chance, Gutfreund, Hess, Holzer, 



Lipmann, McIlwain, Racker, Siekevitz, Slater . . 122 



Control points in phosphorylating respiration and the 

 action of a mitochondrial respiration -releasing factor 



by A. L. Lehninger, C. L. Wadkins and L. F. Remmert 130 



Discussion : Chance, Estabrook, Hess, Holton, Lehninger, 



Lipmann, Racker, Siekevitz, Slater . . . .145 



Some problems in the choice of oxidative pathways of 

 carbohydrate metabolism 



by F. Dickens, Gertrude E. Glock and Patricia McLean 150 



Discussion: Chance, Dickens, de Duve, Glock, Greville, 



Hess, Holzer, King, Potter, Racker . . . 183 



