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DISCUSSION 



Krebs: I noticed that you had very large quantities of DPN-^I. 

 What you determined was intramitochondrial DPN? 



Slater: We determined what is found in an acid extract in order to 

 determine the DPN, and what is found in an alkaline extract in order to 

 determine the DPNH. 



Krebs : That implies that this derivative is rather stable in acid and in 

 alkali. 



Slater: It does not liberate DPN of DPN^I in acid or alkali. One 

 would expect it to be stable in alkaline extract if it were something like 

 a DPNH. 



Lynen : It could be decomposed during the alkaline and acid extrac- 

 tion. You pointed out that the sum of DPN + DPNH is lower at the 

 beginning than after incubation. 



Slater: Yes, it could be decomposed during the acid or alkaline ex- 

 traction. 



