SOME PROBLEMS IN THE CHOICE OF 



OXIDATIVE PATHWAYS OF 



CARBOHYDRATE METABOLISM* 



F. Dickens, Gertrude E. Clock and 

 Patricia McLean 



Courtauld Institute of Biochemistry, Middlesex Hospital Medical 

 School, London 



The recognition of the existence of alternative metabolic 

 pathways of the common foodstuffs, particularly of carbo- 

 hydrate, has posed some rather new and difficult problems for 



* Abbreviations used: 



ATP, ADP adenosine triphosphate, adenosine diphosphate 



C-l/C-6 ratio ratio of i^COg from [l-"C]/[6-i*C]glucose 



DAB 4-dimethylaminoazobenzene 



DHA dihydroxyacetone 



DHAP dihydroxyacetone phosphate 



DPN, TPN diphosphopyridine nucleotide, triphosphopyridine nucleotide 



E-M Embden-Meyerhof (glycolytic) pathway 



FIP, F6P, fructose- 1 -phosphate, fructose-6-phosphate, 



Fl : 6P2 fructose-l : 6-diphosphate 



AG' change of free energy at pH 7 in kg. cal. (Krebs and Kornberg, 



1957) 



GlP, G6P, glucose- 1 -phosphate, glucose-6-phosphate, 



Gl : 6P2 glucose-1 : 6-diphosphate 



D-GA3P D-glyceraldehyde-3-phosphate 



SH7P sedoheptulose-7-phosphate 



Er4P erythrose-4-phosphate 



OAA oxaloacetate 



HMP hexose monophosphate 



ITP, IDP inosine triphosphate, inosine diphosphate 



Pentose P pentose-5-phosphate 



PEP phosphoeno/pyruvate 



6-PG 6-phosphogluconate 



RNA ribonucleic acid 



R5P ribose-5-phosphate 



Ru5P ribulose-5-phosphate 



Xu5P xylulose-5-phosphate 



TA transaldolase 



TK transketolase 



UDPG uridine diphosphate glucose 



UTP, UDP uridine triphosphate, uridine diphosphate 



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