266 



F. Lynen, et aL 



tion; ATP is synthesized in the cytoplasm again, and conse- 

 quently the rate of sugar phosphorylation increases to the 

 anaerobic value. The pattern of the adenine nucleotides and 



lOmin, 



Fig. 7. Initiation of fermentation by cyanide. 



Yeast, 10 per cent ; glucose, 2 per cent ; in -02 m citrate 



buffer, pH 5-4; temp. 15°; oxygenated; 0-001 m-KCN 



added at arrow. Rate of fermentation was determined 



by the accumulation of ethanol. 



the inorganic phosphate in respiring and fermenting cells is 

 depicted in Fig. 6. 



Experimental support for this theory was provided by a 

 series of experiments carried out by Netter and Schuegraf 

 (1958, unpublished). The changes of inorganic phosphate, 

 ADP, ATP and hexose phosphates were followed when 



