384 



Subject Index 



Metal contamination, effect on 



inhibition of glycolysis, 240-242 

 Methionine, in bacteria, 299 

 Methylene blue, as uncoupling 



agent, 134 

 Microsomal membranes, isolation 



of, 25-26 

 Microsomes, cytochrome c re- 

 ductase in, 54r-55, 57 

 enzymic activity of, 26-29, 30 

 in glutamine synthesis, 37 

 Mitochondria, activity of adenosine 



phosphatase in, 59-60 

 adenosine affinity of, 97, 101, 128, 



129 

 ATP/ADP ratio in, 122-123, 128, 



129 

 adenosine diphosphate in, 215 

 adenosine triphosphate in, 226 

 affinity of for substrates, 112-113 

 ageing of, effect on cell respiration, 



66-68, 72 

 alterations in, causing changes in 



electron pathways, 199 

 and cytochrome reductase, 54-55, 



57 

 changes in during respiration, 274- 



275 

 chemical properties of, 25 

 control of by phosphorylation 



system, 117-118 

 DPN derived from, 74, 75 

 effect of age on, 234 

 effect of calcium on, 103-106, 127, 



128 

 effect of dicoumarol, 107-112 

 effect of magnesium on, 101-103, 



127 

 effect of tri-iodothyronine, 123-124 

 effect of uncoupling agents, 133- 



138 

 effect on glycolysis, 232-236 

 effect on reduced triphosphopyri- 



dine nucleotide, 245-247 

 electron pathways in, 194, 198, 



200 

 exchange reactions of adenosine 



triphosphate in, 130-133, 134, 



135, 136, 137, 144, 146-148 

 in oxidative phosphorylation, 74r- 



78, 83-84 

 in Pasteur effect, 274 

 isolation of, 231 



naturally occurring controlling fac- 

 tors in, 138-144, 146 



Mitochondria, 



oxidation of triphosphopyridine 



nucleotide in, 159-160, 183 

 Pasteur effect produced by, 230 

 phosphate affinity of, 97-101 

 phosphorylation efficiency of, 106- 



107 

 pyridine nucleotide in, 113-115 

 relationship with endoplasmic re- 

 ticulum, 19, 46, 47, 48, 49 

 respiratory control in, 93-97 

 R factor in, 140-144, 148 

 role of in oxidative phosphoryla- 

 tion, 269 

 transfer of material in, 274-275 

 uncoupling agents isolated from, 

 72, 140, 146 

 Mitochrome, 139 



formation of, 68-69, 70 

 uncoupling activity of, 69 

 Muscle, glycogen synthesis in, 188- 



193 

 Muscle stimulation, causing oxida- 

 tion of diphosphopyridine nucleo- 

 tide, 79 



Naphthoquinone, in oxidative phos- 

 phorylation, 203, 204 



Nucleic acids, in bacteria, 298, 299, 

 300, 303, 305, 308 

 in cells, 323, 341 

 incorporation of guanine into, 343 



Oleic acid, uncoupling by, 71 

 Oxaloacetate, in carbohydrate meta- 

 bolism, 161, 163 

 Oxidation- reduction systems, in 



carbohydrate metabolism, 250 

 Oxidative pathways in carbo- 

 hydrate metabolism, 150-187 

 Oxidative phosphorylation, ade- 

 nosine triphosphate in, 219, 220, 

 221 

 diphosphopyridine nucleotide in, 



62, 65, 74r-78, 79, 83-89 

 effect of ageing of submitochon- 



drial fragments, 134, 135, 137 

 effect of arsenate on, 134, 137, 147 

 effect of 3-hydroxybutyrate, 196- 



197 

 effect of R factor, 140-144, 146, 



148 

 effect of uncoupling agents, 133- 



138, 146 

 effect on glucose uptake, 264 



