NEUROMUSCULAR TRANSMISSION IN INVERTEBRATES 



253 



response, and contractions following single shocks 

 were then commonly seen. These drugs did not evoke 

 any contraction in the absence of other stimuli. 

 Depressant drugs were also found. Ergotoxin (io^°) 

 and trimethylamine oxide (io~'), respectively, re- 

 duced and abolished sphincter contraction. The fact 

 that such high concentrations and long application 

 times were required need not argue against the signifi- 

 cance of the.se results, since there are probably con- 

 siderable barriers to diffusion in the intact animal, 

 and all effects observed were full)- reversible. Magne- 



sium chloride also depresses neuromuscular transmis- 

 sion both in anemones (68) and in medusae (13) and 

 in these cases high concentrations and prolonged 

 exposures are also necessary. 



While the above experiments may provide interest- 

 ing clues, they do not allow any specific conclusions 

 about the mechanism of transmission, and there would 

 not seem to be any a prion basis on which to decide 

 whether this process occurs in these animals by local 

 circuit action ('electrically') or by means of some 

 mediator ('chemically'). 



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