SEPARATION OF GROWTH AND DIFFERENTIATION 



159 



Figs. 1-4. Embryos of Amblystoma punctatum of equal age, which have been erabedded for 

 10 days In agar. According to whether they were Included completely or 

 partially, they exhibit total or local growth inhibitions respectively. 

 Cytologlcal differentiation has not been affected. Figure 4 shows the agar 

 matrix still present. 



From Holtfreter, 1914-5: Anat. Bee. 93:59. 



REFERENCES: 



Adblph, E. F. , 1951 - "Body size as a factor In the metamorphosis of tadpoles." Biol. 

 Bull. 61:576, 



Barnes, M. R., 19^11+ - "The metabolism of the developing Rana plplens as revealed hy 

 specific Inhibitors." Jour, Exp. Zool. 95:399- 



Berrlll, N. J., 1935 - "Cell division and differentiation In asexnial and sexual develop- 

 ment." Jour. Morph. 57:353- 



Bliss, A. E,, 1914-0 - "The effect of trypsin on development of Rana plplens," Proc, Soc. 

 Exp. Biol. & Med. 1+5:769. 



Blount, R., 1955 - "Size relationships as influenced by plttdtaiT- rudiment Ingilantatlon 

 and extirpation In the urodele embryo," Jour. Exp. Zool. 70:1. 



Bodensteln, D., I9I4-7 - "The effects of nitrogen mustard on embryonic amphlblsin develop- 

 ment. I. Ectodermal effects." Jour. Exp. Zool. 10l4-:511. 



Boerema, I., I929 - "Die Dynamic des Medullarrohrschlusses. " Arch. f. Ent. mech. 115:601. 



Bragg, A. N., I958 - "The organization of the early embryo of Buto cognatus as revealed 

 especially by the mitotic Index." Z. Zellf. mirk. Anat. Berlin. 28:15l4- (see also 

 1959; Bio. Bull. 77:268). 



Brlggs, E., I9I+6 - "Effects of the growth Inhibitor, hexenolactone, on frog, embryos." 

 Growth.- 10:1+5- 



Brlggs, J, B. & R. W, Brlggs, I9I+5 - "The effects of water-soluble carcinogen on early 

 frog development," Cancer Research. 5:1- 



Brown, L. A., I927 - "On the nature of the equation for growth processes," Jour, G«n. 

 Physiol. 11:57, 



Brown, M. G. & V. Hamburger, 191+1 - "Density studies on amphibian embryos with special 

 reference to the mechanism of organizer action." Jour. Exp. Zool. 88:555- 



