CLARK, G. 
emergency mechanism which will keep body temperature from going 
above that level and Roche, in 189 8, found that same thing; you could 
drive an animal's temperature up by considerable amounts, up to 
this level, but to go beyond this level you had to either exhaust the 
animal by a prolonged application or else really provide a severe 
stimulant. 
DR. CLARK: You are quite correct in that, and it is not the 
usual thing right after anterior hypothalamic lesion, to get a temper- 
ature above 41.1 C or 41.7 C. I have one cat that had a tempera- 
ture of 43.6 C the morning after the operation. 
MR. ADAMS: This point that Dr. Freeman brings out I think is 
true. It is also seen in bats which may be essentially poikilothermic 
at lower ambient temperatures at rest but which can be seen to 
regulate their temperatures at higher levels. Since you mentioned 
that the upper temperature level is dependent on ambient tempera- 
ture, 1 think that this might preclude accepting this explanation 
completely. 
DR. FREEMAN: We have done the same thing with cats given 
strychnine, where they are given serial convulsions, and you can 
control this by the amount of strychnine that you give. By pounding 
on the table at fairly regular intervals, you can induce a series 
of repetitive convulsions which will drive the animal's body 
temperature up to about this level, and then it will flatten off, even 
though convulsions continue. About this time, also, they will start to 
pant. Another way of doing it is to put them in a very hot environ- 
ment. This is an intact normal cat. Put him in an environment of 
o 
48 C, which is quite uncomfortable, and he will make vigorous 
attempts to escape but will not pant. Now, their body temperature 
will rise rapidly during this period. I could not get continuous 
records because they weretooactive, but abruptly they will collapse 
and start to pant vigorously. They just lie down; if you take them out 
at that point, you will find that their body temperatures are 40.7 C. 
They go so high and then no further. So, there is something that goes 
on here, and this something, this mechanism — whatever it is — is 
still intact in the animals you described. 
MR. ADAMS: Dr. Clark, were those lesions you reported on this 
afternoon or this morning dual lateral lesions? 
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