xii CONTENTS 



PAGE 



Myocardial Irritability in Experimental Immersion Hypothermia — A. H. 



Hegnaiter and B. G. Covino 327 



Ventricular fibrillation vs. asystole. Diastolic thresholds in relation to character of 

 death in hypothermia. pH and ventricular excitability. pH and electrocardiogram. 

 Electrolyte balance across myocardium. Myocardial penetrance of calcium. Exoge- 

 nous calcium and ventricular fibrillation. 



Discussion: 



F. J. Lczvis, B. F. Flofjman, F. Gollan, A. Riberi, and J. Caliii 340 



Use of CO2 to reduce ventricular fibrillation. Nonuniform changes in heart muscle. 

 Value of coronary artery perfusion, infiltration of S-A node with procaine, sympa- 

 thetic block, and vagal stimulation. 



REVIEW AND APPRAISAL OF PART III — C. McC. Brooks and B. F. Hoffman. . . 355 



Oxygen supply and cardiac metabolism. Analysis of functional reactions. Species 

 and tissue peculiarities. High and low diastolic thresholds. Ion shifts. Significance 

 of pH and PCO2 changes. Cardiac efficiency in hypothermia and rewarming. Fac- 

 tors responsible for ventricular fibrillation and asystole at inconveniently high tem- 

 peratures : adequacy of perfusion. 



Part IV — Clinical Application of Induced Hypothermia 



Hypothermia in Neurosurgery — E. H. Botterell and IV. M. Loughced 363 



Local treatment of intracranial aneurysms and arteriovenous malformation. "Slack" 

 brain. Results in 40 patients. 



Discussion: 



G. H. Clozves, Jr., W. M. Lougheed, and E. H. Botterell 368 



Effect of Hypothermia on Tolerance to Hemorrhagic Shock — E. W. Fried- 

 man, D. Davidoff, and Jacob Fine 369 



Veno-venous cooling vs. immersion in ice water. Tolerance to hemorrhage. Use 

 of antibiotics. 



Discussion: 



E. Frank 378 



Experimental Observations on the Influence of Hypothermia and Autonomic 

 Blocking Agents on Hemorrhagic Shock — R. C. Overton and M. E. 

 De Bakcy 381 



Effects of hypothermia alone, chlorpromazine alone, and both together on course of 

 "irreversible hemorrhagic shock" in dogs. 



Hypothermia and Experimental Myocardial Infarction — Charles IJuggins . . . 392 



Obstruction of anterior descending branch of left coronary artery in dog. Toler- 

 ance to hypothermia within 3-5 days. 



Treatment of the Seriously 111, Febrile Patient with Surface Cooling — 



F. J. Lczvis, D. M. Ring, and J. F. Alden 394 



Clinical experience with 25 patients. 



