CONTENTS ix 



Part II — The Effects of Hypothermia on Specific S'i stems 



PAGE 



A. Cardiovascular 



Cardiovascular Functions in Deep Hypothermia — //. R. D'Amato 146 



Heart rate and arterial pressure. Nature of bradycardia. Coronary circulation. Car- 

 diac output and work. Blood flow. Summary. 



Discussion: 



I. K. R. McMillan and E. Friedman 155 



The Circulation During Rewarming — Henry Sivaii 161 



Cardiac output inadequate. Left ventricular oxygen consumption and efficiency. 

 Discussion: 



R. 0. Heimbecker and J. Fine 161 



Coronary Blood Flow During Hypothermia — R. M. Berne 165 



Resistance in coronary bed with cooling. Coronary sinus. Potassium. Relation of 

 coronary inflow to period of isometric relaxation. 



B. Endocrine 



The Effect of Hypothermia on Pituitary ACTH Release and on Adrenal 

 Cortical and Medullary Secretion in the Dog — D. M. Flume. R. H. Eg- 

 dalil, and D. H.Nelson 1 70 



Summary of work on blood ACTH and on adrenal corticosteroid, epinephrine, and 

 norepinephrine output in hypothermia. 



Discussion : 



A. D. Keller, M. E. De Bakey. J. R. Pappenheimer, and F. D. Moore. . 173 



The Effect of Hypothermia on the Peripheral Serum Levels of Free 17- 



Hydroxycorticoids in the Dog, and in Man — /['. F. Bernhard 175 



Reduction in adrenocortical output balanced by reductions in utilization, conjugation, 

 or excretion. Postsurgical rise in cortical level depressed by hypothermia. Immer- 

 sion cooling as a stress. 



Discussion : 



J. Calm and H. Szvan 1 78 



C. Hematology 



Some Problems of Hematology in Flypothermia : An Introduction — U'il- 



liam H. Crosby, Jr 183 



Changes in levels of platelets, leukocytes, and hematocrit. 



The Effect of Hypothermia on Platelets and White Cells in Dogs — T. J. Villa- 



lobos, E. Adelson, and P. A. Riley 186 



Sequestration of platelets. Role of liver and spleen. 



