CONTENTS 



PAGli 



Foreword — P. S. Owen iii 



Introduction — R. D. Dripps, CJiairtuan a- 



Part I — General Physicochemical and Physiologic Considerations 



OF Hypothermia 



Some Considerations of Physicochemical l^^actors in Hypotliermia — /). E. S. 



Brozvii 1 



Temperature coefficients of cellular reactions. Bacterial Ininincsccnce. Scrum clio- 

 linesterase. Cellular processes. Cardiac contractility. Treppe. 



Etifects of Hypothermia on General ^letaholism — S. M. Honvth and G. B. 



Spnrr 8 



Species variation. Cellular response to cooling. Temperature gradients. Oxygen 

 consumption. Respiration. Patterns of heat loss. Changes in protein, fat, and carbo- 

 hydrate metabolism. Fat necrosis. Drug action and temperature. Electrolytes. Acid- 

 base balance. Body water. 



The Effect of Low Temperatin"es upon Intracellular Potassium in Isolated 



Tissues — 7. M. Taylor 26 



Normal distribution of potassium and sodium. Shift of potassium from cell with 

 cooling. Critical temperature for potassium escape in rat and hamster diaphragm. 

 Potassium exchange in perfused, isolated rat heart. Relation of intracellular ix>tas- 

 sium loss to death from hypothermia. 



Potassium Exchange in Perfused ]\Iainmalian Skeletal ]\Iu.scle — E. M. 



Renkin 32 



Perfused cat leg. Loss of potassium at body temperature. Loss of i>otassium at 

 3°-9° C. Temperature coefficient of potassium equilibration. Difiference between per- 

 fused and immersed tissues. Potassium loss with acidosis. 



Electrolyte Transfer during Hypothermia — Frank GoUan ,S7 



Fate of injected radioactive potassium, sodium, and bromine at 38° and 23° C. 

 Acute anoxia. K/Na ratio. Oxygen consumption. 



Myocardial Balance of Potassium — Henry Swan 42 



Coronary sinus sampling. Potassium and i)liosi)liorus lialance of myocardium at 

 30° C. Influence of acidosis. 



Effects of Low Body Temperatiu'e on Tissue Oxygen Utilization — E. E. 



AdoJph " ' 44 



Oxygen consumption. Arterial pOa and pCO^. Cardiac output. Hlood distribution. 

 Oxygen debt. Enzymic transfer of oxygen. 



vii 



73953 



